The resignation, which has been confirmed by EDF Group chairman Jean-Bernard Levy, comes over Piquemal’s concerns that the project could put the company’s financial position at risk.
Levy said: "With the support of its shareholder, the state, EDF can confirm that it is looking to invest in two reactors at Hinkley Point under the best possible financial conditions for the Group, with the objective of making a final investment decision in the near future.
"EDF relies on very strong operational results, the internal transformation and the savings plans launched in 2015, and on investments in support of the energy transition and the renewal of the nuclear industry."
The latest move follows the resignation of EDF Hinkley Point project director Chris Bakken in February 2016.
In January 2016, EDF said it has delayed its FID on the Hinkley Point C nuclear plant.
CGN earlier agreed to acquire 33.5% stake in the project in exchange for investing €6bn through its new company, known as General Nuclear International (GNI).
Scheduled to be commissioned in 2025, the Hinkley Point C project is expected to meet the 7% of the UK’s electricity needs.