This is part of a regional upgrade to substations and is expected to cost $80m.
During the construction phase, it is expected to create up to 200 jobs.
Once substation goes online, it is expected to improve the reliability of power in the region.
Ameren southeast Missouri division director Bob Dixon was quoted as saying by Southeast Missourian: "We know that the region is growing, and we are here to meet that demand of growth."
Dixon added the upgrades are crucial for the firm because one of the new lines will transmit electricity to Cape Girardeau’s hospitals.
Cape Girardeau city manager Scott Meyer and Gordonville Mayor J.D. King were also present among others at the groundbreaking event called Cape Girardeau Electric Reliability Program, which is an upgrade program that includes new substation on Route K and a second substation nearby, new and replacement of transmission lines to several substations in Cape Girardeau.
These projects are likely to be completed by May 2016.
